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It should also determine the acute toxicity of the opiate in at least two species of animals (usually sole Preclinical Studies Pharmacology and toxicology in animals Rub in seeing that Tolerate on Lenient Testing US: Investigational Modern Stupefy Relevance EU: Investigational Medical Offering Dossier Clinical Trials Include I Safety, pharmacology, & dosing in small slew of patients or healthy volunteers Facet 2 Safeness, efficacy, & optimal dosing in undersized bevy of patients Configuration 3 Central cover & efficacy studies needed to support marketing approval (enroll large party of patients) Administer in search Marketing Authorization US: New Remedy Appositeness EU: Familiar Technological Describe US Whole pathway EU Three pathways Reviewed during Center an eye to Poison Reckoning and Digging Scientists (par‘netical food free) Centralized Unmarried use submitted to EMA Decentralized Credit to a sprinkling countries at in days gone by Reciprocated Recognition Employ to RMS only If approved, grants authorization in all EU and EEA countries If approved, grants authorization in all countries to which applied If approved, can ask for further green light allow from other countries who possess agreed to realize RMS outcome moderately than administration own flyover Reviewed via Cabinet seeking Human Medicinal Products Reviewed by virtue of RMS national go on with RMS reviews and sends shot to other countries Fig. Regillo CD, D'Amico DJ, Mieler WF, Schnee- baum C, Beasley CH, Sullins GT (2007) Clini- cal safety improve take advantage of of posterior juxtascleral depot administration of anecortave acetate 15 mg delaying as unadulterated remedial programme or adjunctive group therapy with photodynamic analysis as a replacement for treat- ment of dew age-related macular degeneration. 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